Publications

• Pech de Laclause A, Konofal E, Bokov P, Delclaux C, Lecendreux M. Adjustment to lockdown in children and adolescents with narcolepsy in France. J Clin Sleep Med. 2022 Sep 1;18(9):2247-2252. doi: 10.5664/jcsm.10096. PMID: 35698456. Adjustment to lockdown in children and adolescents with narcolepsy in France – PubMed (nih.gov)

• Lecendreux M, Plazzi G, Dauvilliers Y, Rosen CL, Ruoff C, Black J, Parvataneni R, Guinta D, Wang YG, Mignot E. Long-term safety and maintenance of efficacy of sodium oxybate in the treatment of narcolepsy with cataplexy in pediatric patients. J Clin Sleep Med. 2022 Sep 1;18(9):2217-2227. doi: 10.5664/jcsm.10090. PMID: 35689598. Long-term safety and maintenance of efficacy of sodium oxybate in the treatment of narcolepsy with cataplexy in pediatric patients – PubMed (nih.gov)

• Evans R, Kimura H, Alexander R, Davies CH, Faessel H, Hartman DS, Ishikawa T, Ratti E, Shimizu K, Suzuki M, Tanaka S, Yukitake H, Dauvilliers Y, Mignot E. Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2207531119. doi: 10.1073/pnas.2207531119. Epub 2022 Aug 22. PMID: 35994639; PMCID: PMC9436334. Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients – PubMed (nih.gov)

• Strauss M, Griffon L, Van Beers P, Elbaz M, Bouziotis J, Sauvet F, Chennaoui M, Léger D, Peigneux P. Order matters: sleep spindles contribute to memory consolidation only when followed by rapid-eye-movement sleep. Sleep. 2022 Apr 11;45(4):zsac022. doi: 10.1093/sleep/zsac022. PMID: 35037060. Order matters: sleep spindles contribute to memory consolidation only when followed by rapid-eye-movement sleep – PubMed (nih.gov)

• Dauvilliers Y, Arnulf I, Foldvary-Schaefer N, Morse AM, Šonka K, Thorpy MJ, Mignot E, Chandler P, Parvataneni R, Black J, Sterkel A, Chen D, Skobieranda F, Bogan RK. Safety and efficacy of lower-sodium oxybate in adults with idiopathic hypersomnia: a phase 3, placebo-controlled, double-blind, randomised withdrawal study. Lancet Neurol. 2022 Jan;21(1):53-65. doi: 10.1016/S1474-4422(21)00368-9. PMID: 34942138. Safety and efficacy of lower-sodium oxybate in adults with idiopathic hypersomnia: a phase 3, placebo-controlled, double-blind, randomised withdrawal study – PubMed (nih.gov)

• Barateau L, Lecendreux M, Chenini S, Rassu AL, Lopez R, Pesenti C, Jaussent I, Béziat S, Dauvilliers Y. Measurement of Narcolepsy Symptoms in School-Aged Children and Adolescents: The Pediatric Narcolepsy Severity Scale. Neurology. 2021 Aug 3;97(5):e476-e488. doi: 10.1212/WNL.0000000000012272. Epub 2021 May 24. PMID: 34031200. Measurement of Narcolepsy Symptoms in School-Aged Children and Adolescents: The Pediatric Narcolepsy Severity Scale – PubMed (nih.gov)

• Lecomte A, Barateau L, Pereira P, Paulin L, Auvinen P, Scheperjans F, Dauvilliers Y. Gut microbiota composition is associated with narcolepsy type 1. Neurol Neuroimmunol Neuroinflamm. 2020 Oct 9;7(6):e896. doi: 10.1212/NXI.0000000000000896. PMID: 33037102; PMCID: PMC7577550. Gut microbiota composition is associated with narcolepsy type 1 – PubMed (nih.gov)

• Thieux M, Zhang M, Marcastel A, Poitrinal A, Vassias F, Guyon A, Revol O, Mazza S, Guignard-Perret A, Franco P. Sleep and Psychosocial Characteristics of Children with Narcolepsy According to Their Intellectual Profile: A Case-Control Study. J Clin Med. 2022 Aug 10;11(16):4681. doi: 10.3390/jcm11164681. PMID: 36012919; PMCID: PMC9410520. Sleep and Psychosocial Characteristics of Children with Narcolepsy According to Their Intellectual Profile: A Case-Control Study – PubMed (nih.gov)

• Zhang M, Thieux M, Inocente CO, Vieux N, Arvis L, Villanueva C, Lin JS, Plancoulaine S, Guyon A, Franco P. Characterization of rapid weight gain phenotype in children with narcolepsy. CNS Neurosci Ther. 2022 Jun;28(6):829-841. doi: 10.1111/cns.13811. Epub 2022 Feb 25. PMID: 35212159; PMCID: PMC9062543. Characterization of rapid weight gain phenotype in children with narcolepsy – PubMed (nih.gov)

• Nigam M, Hippolyte A, Dodet P, Gales A, Maranci JB, Al-Youssef S, Leu-Semenescu S, Arnulf I. Sleeping through a pandemic: impact of COVID-19-related restrictions on narcolepsy and idiopathic hypersomnia. J Clin Sleep Med. 2022 Jan 1;18(1):255-263. doi: 10.5664/jcsm.9556. PMID: 34314345; PMCID: PMC8807898. Sleeping through a pandemic: impact of COVID-19-related restrictions on narcolepsy and idiopathic hypersomnia – PubMed (nih.gov)

• Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ. European guideline and expert statements on the management of narcolepsy in adults and children. Eur J Neurol. 2021 Sep;28(9):2815-2830. doi: 10.1111/ene.14888. Epub 2021 Jun 25. PMID: 34173695. European guideline and expert statements on the management of narcolepsy in adults and children – PubMed (nih.gov)

• Thieux M, Zhang M, Marcastel A, Herbillon V, Guignard-Perret A, Seugnet L, Lin JS, Guyon A, Plancoulaine S, Franco P. Intellectual Abilities of Children with Narcolepsy. J Clin Med. 2020 Dec 17;9(12):4075. doi: 10.3390/jcm9124075. PMID: 33348677; PMCID: PMC7766444. Intellectual Abilities of Children with Narcolepsy – PubMed (nih.gov)

• Barateau L, Lopez R, Chenini S, Pesenti C, Rassu AL, Jaussent I, Dauvilliers Y. Depression and suicidal thoughts in untreated and treated narcolepsy: Systematic analysis. Neurology. 2020 Nov 17;95(20):e2755-e2768. doi: 10.1212/WNL.0000000000010737. Epub 2020 Sep 22. PMID: 32963102. Depression and suicidal thoughts in untreated and treated narcolepsy: Systematic analysis – PubMed (nih.gov)

• Zhang M, Inocente CO, Villanueva C, Lecendreux M, Dauvilliers Y, Lin JS, Arnulf I, Gustin MP, Thieux M, Franco P. Narcolepsy with cataplexy: Does age at diagnosis change the clinical picture? CNS Neurosci Ther. 2020 Oct;26(10):1092-1102. doi: 10.1111/cns.13438. Epub 2020 Aug 6. PMID: 32761857; PMCID: PMC7539846. Narcolepsy with cataplexy: Does age at diagnosis change the clinical picture? – PubMed (nih.gov)

• Sauvet F, Erblang M, Gomez-Merino D, Rabat A, Guillard M, Dubourdieu D, Lefloch H, Drogou C, Van Beers P, Bougard C, Bourrrilhon C, Arnal P, Rein W, Mouthon F, Brunner-Ferber F, Leger D, Dauvilliers Y, Chennaoui M, Charvériat M. Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40-hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target. Br J Clin Pharmacol. 2019 Nov;85(11):2623-2633. doi: 10.1111/bcp.14098. Epub 2019 Sep 15. PMID: 31419329; PMCID: PMC6848897. Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40-hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target – PubMed (nih.gov)

• Lacaux C, Izabelle C, Santantonio G, De Villèle L, Frain J, Lubart T, Pizza F, Plazzi G, Arnulf I, Oudiette D. Increased creative thinking in narcolepsy. Brain. 2019 Jul 1;142(7):1988-1999. doi: 10.1093/brain/awz137. PMID: 31143939. Increased creative thinking in narcolepsy – PubMed (nih.gov)

• Franco P, Dauvilliers Y, Inocente CO, Guyon A, Villanueva C, Raverot V, Plancoulaine S, Lin JS. Impaired histaminergic neurotransmission in children with narcolepsy type 1. CNS Neurosci Ther. 2019 Mar;25(3):386-395. doi: 10.1111/cns.13057. Epub 2018 Sep 17. PMID: 30225986; PMCID: PMC6488909. Impaired histaminergic neurotransmission in children with narcolepsy type 1 – PubMed (nih.gov)

• Leger D, Gauriau C, Tonetti L, Lantin M, Filardi M, Philip P, Faraut B, Natale V. Using actigraphy to assess sleep and wake rhythms of narcolepsy type 1 patients: a comparison with primary insomniacs and healthy controls. Sleep Med. 2018 Dec;52:88-91. doi: 10.1016/j.sleep.2018.07.024. Epub 2018 Aug 31. PMID: 30286385. Using actigraphy to assess sleep and wake rhythms of narcolepsy type 1 patients: a comparison with primary insomniacs and healthy controls – PubMed (nih.gov)

• Al Shareef SM, Basit S, Li S, Pfister C, Pradervand S, Lecendreux M, Mayer G, Dauvilliers Y, Salpietro V, Houlden H, BaHammam AS, Tafti M. Kleine-Levin syndrome is associated with LMOD3 variants. J Sleep Res. 2019 Jun;28(3):e12718. doi: 10.1111/jsr.12718. Epub 2018 Jun 19. Erratum in: J Sleep Res. 2020 Jun;29(3):e12849. PMID: 29923248. Kleine-Levin syndrome is associated with LMOD3 variants – PubMed (nih.gov)

• Lecendreux M, Churlaud G, Pitoiset F, Regnault A, Tran TA, Liblau R, Klatzmann D, Rosenzwajg M. Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells. PLoS One. 2017 Jan 20;12(1):e0169836. doi: 10.1371/journal.pone.0169836. PMID: 28107375; PMCID: PMC5249232. Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells – PubMed (nih.gov)

• Leu-Semenescu S, Le Corvec T, Groos E, Lavault S, Golmard JL, Arnulf I. Lithium therapy in Kleine-Levin syndrome: An open-label, controlled study in 130 patients. Neurology. 2015 Nov 10;85(19):1655-62. doi: 10.1212/WNL.0000000000002104. Epub 2015 Oct 9. PMID: 26453648. Lithium therapy in Kleine-Levin syndrome: An open-label, controlled study in 130 patients – PubMed (nih.gov)

• Dodet P, Chavez M, Leu-Semenescu S, Golmard JL, Arnulf I. Lucid dreaming in narcolepsy. Sleep. 2015 Mar 1;38(3):487-97. doi: 10.5665/sleep.4516. PMID: 25348131; PMCID: PMC4335518. Lucid dreaming in narcolepsy – PubMed (nih.gov)

• Arnulf I, Rico TJ, Mignot E. Diagnosis, disease course, and management of patients with Kleine-Levin syndrome. Lancet Neurol. 2012 Oct;11(10):918-28. doi: 10.1016/S1474-4422(12)70187-4. PMID: 22995695. Diagnosis, disease course, and management of patients with Kleine-Levin syndrome – PubMed (nih.gov)